Research of the Activity of Glutathionperoxidase and the Content of Glutathion in Various Structural and Functional Divisions of the Radrain Brain when Exposed to Radiation

Purpose: To study the specific content (per 1 g of tissue) reduced glutathione and activity enzyme antioxidant protection peroxidase conjugated with it in various structural functional parts rat brain when exposed to ionizing radiation at a dose 6 Gy. Material methods: The studies were carried out on white outbred rats subjected single total γ-radiation an average lethal determined irradiated animals: cortex, stem, cerebellum. A group non-irradiated intact served as control. Results: In control animals, cytoplasm is significantly higher than mitochondria obtained from cells cerebellum, stem. highest cerebral followed by cerebellum brainstem. Significant violations studied biochemical parameters brainstem found dynamics damage. Thus, particular, cortex 7th day after exposure decreases approximately 66 % compared indicators animals. Conclusions: Exposure Gy leads decrease brain, especially injury. detected changes acute sickness correlate peroxidase, directly coupled this antioxidant.